The proposed research objectives are highly compatible with the current state of knowledge in the field of Biomedical Engineering and Computational Biophysics. The investigation of glucocorticoid drug budesonide interaction with lung surfactant monolayer is essential for determining the effect of drug on the structure, compressibility, and dynamical properties of the monolayer. The drug-monolayer investigation can also reveal the precise drug concentrations needed to control the biophysical activities of monolayers without compromising their stability. By preventing systemic complications, this knowledge aids in drug dosage measurement and the development of medical treatments and drug carriers for lung disorders. The chemical characteristics of the drug and monolayer interaction as well as the drug adsorption process on the surfactant layer have not been adequately explained by prior in vivo and in vitro studies on the lung surfactant exposed to corticosteroid treatments. Learning more about the interactions of budesonide with the monolayer components and their biophysical features at the special and temporal resolution in nanoscale has been made feasible by molecular dynamics (MD) simulation research. As a result, in vitro and in vivo tests have encountered difficulties that can be overcome in in silico (MD simulation) studies. Two well-known MD simulation methodologies, such as atomistic MD simulation and Coarse-Grained MD simulation, are used to study the lipid molecules and their complexes exposed to drugs. Atomistic MD simulation is the best technique if the study's main objective is to look into the specifics of small drug molecules' interactions with lipids, including hydrogen bonds between the drug and lipid head groups and/or differences between similar drug molecules' interactions with membrane components. On the other hand, due to the current processing expense of the atomistic simulation, atomistic MD simulation will not be the best option if we want to explore the partitioning, adsorption, and diffusion mechanism of drug molecules in the monolayer surface. Then, as opposed to using an atomistic model, Coarse-Grained MD simulation would be the most trustworthy and effective technique. The majority of the investigations using MD simulation to date have dealt with antimicrobial peptides, antibiotics, non-steroid, hydrophobic/hydrophilic nanoparticles, carbon nanoparticles, gelatine nanoparticles, hazardous nanoparticles, and gold nanoparticles with lung surfactant monolayer. The lipid monolayer has received little attention in the studies, despite the significance of the corticosteroid drug-monolayer interaction in guaranteeing the proper dose of the steroid that can sustain the regular breathing process in the alveoli. Since corticosteroids influence monolayer, it is imperative to model monolayer in their presence to understand how corticosteroids and monolayer components affect the monolayer's structural dynamics and biophysical properties. In order to ascertain the impact of corticosteroids and monolayer components on monolayer structure, and dynamical, and biophysical aspects, the investigation of corticosteroid medication interactions with lung surfactant monolayer should be given high importance. This involves modeling surfactant monolayer in the presence of various corticosteroids.