Study of the Drug Interaction and Delivery into the Lung Airways by the In Vitro and In Silico Approach

The proposed project will explore the concentration-dependent effects of aerosolized drug particle transportation and deposition on the lung airways. This project will demonstrate the shape and size specific drug deposition pattern in the lung airways and illustrate the deposition hot spot. Deposition hot spot for different patients will be different. Depending on the deposition hot spot, different inhalation devices will be developed. After diagnosis, the individual patient will use the appropriate inhalation device, and it will significantly increase the efficiency of the drug delivery. The long-term outcomes from this project have a strong likelihood of generating an economic benefit across the general population, as well as the industries where lung-related diseases can affect productivity and worker availability. The expected initial outcome of this project will attract the pharmaceutical industry, and these applicants wish to apply different Linkage project for future funding, which will eventually benefit for country. About 5.50% of Bangladeshi, aged 40 years or more have some breathing shortage and this figure increases day by day in Bangladesh due to different lung diseases including asthma, lung cancer and obstructive pulmonary diseases (COPD). The successful completion of this project will help to minimize the respiratory diseases, and which will benefit the society. The commercialization of the newly designed drug delivery device will benefit the economy.